Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8+ T Cells in Head and Neck Cancer.

@article{Krishna2018HumanPV,
  title={Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8+ T Cells in Head and Neck Cancer.},
  author={Sri Krishna and Peaches Ulrich and Eric Wilson and Falguni Parikh and Pooja Narang and Shanshan Yang and Amelia K Read and Seunghee Kim-Schulze and Jin G Park and Marshall Posner and Melissa A. Wilson Sayres and Andrew G. Sikora and Karen S. Anderson},
  journal={Cancer research},
  year={2018},
  volume={78 21},
  pages={
          6159-6170
        }
}
  • Sri Krishna, Peaches Ulrich, +10 authors Karen S. Anderson
  • Published in Cancer research 2018
  • Medicine
  • Human papillomavirus subtype 16 (HPV16) is the primary cause of an increasing number of head and neck squamous cell carcinomas (HNSCC), providing strong rationale for T-cell immune therapies against HPV+ HNSCC. Here we assess immunogenicity of HPV16-specific CD8+ T cells (CTL) and characterize HPV-specific mechanisms of T-cell dysfunction. We identified 16 strong and 29 moderately immunogenic CTL-epitopes from HPV16 E2, E6, and E7 antigens restricted by 12 common HLA class I alleles. E2… CONTINUE READING

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