Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

@article{GardnerStephen2004HumanPV,
  title={Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.},
  author={Dione Gardner-Stephen and J. M. Heydel and Amit Goyal and Yuan Lu and Wen Xie and Tim H. Lindblom and Peter I. Mackenzie and Anna Radomińska-Pandya},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2004},
  volume={32 3},
  pages={
          340-7
        }
}
The pregnane X receptor (PXR) has three known major transcript variants resulting from alternative splicing. The less well characterized variants T2 and T3 are identical to the well described variant T1 except for a 39-amino acid N-terminal extension in T2 and an internal 37-amino acid deletion in T3. We have developed reverse transcription-polymerase chain reaction (RT-PCR) methods to detect and quantify each human PXR (hPXR) in human liver and intestinal tissues and HepG2 and Caco-2 cell… CONTINUE READING
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