Human PAD4 regulates histone arginine methylation levels via demethylimination.

  title={Human PAD4 regulates histone arginine methylation levels via demethylimination.},
  author={Yanming Wang and Joanna Wysocka and Joyce Sayegh and Young-Ho Lee and Julie R. Perlin and Lauriebeth Leonelli and Lakshmi S Sonbuchner and C H Mcdonald and Richard G. Cook and Yali Dou and Robert G Roeder and Steven W. Clarke and Michael R Stallcup and C David Allis and Scott A Coonrod},
  volume={306 5694},
Methylation of arginine (Arg) and lysine residues in histones has been correlated with epigenetic forms of gene regulation. Although histone methyltransferases are known, enzymes that demethylate histones have not been identified. Here, we demonstrate that human peptidylarginine deiminase 4 (PAD4) regulates histone Arg methylation by converting methyl-Arg to citrulline and releasing methylamine. PAD4 targets multiple sites in histones H3 and H4, including those sites methylated by coactivators… CONTINUE READING
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