Human Ovarian Carcinoma Cells

In the present work, we studied the effects of fenretinide (HPR), a hydroxyphenyl derivative of all-trans-retinoic acid, on sphingolipid metabolism and expression in human ovarian carcinoma A2780 cells. A2780 cells, which are sensitive to a pharmacologically achievable HPR concentration, become 10-fold more resistant after exposure to increasing HPR… CONTINUE READING