Human Osteoarthritic Cartilage Shows Reduced In Vivo Expression of IL-4, a Chondroprotective Cytokine that Differentially Modulates IL-1β-Stimulated Production of Chemokines and Matrix-Degrading Enzymes In Vitro

@inproceedings{Assirelli2014HumanOC,
  title={Human Osteoarthritic Cartilage Shows Reduced In Vivo Expression of IL-4, a Chondroprotective Cytokine that Differentially Modulates IL-1β-Stimulated Production of Chemokines and Matrix-Degrading Enzymes In Vitro},
  author={Elisa Assirelli and Lia Pulsatelli and Paolo Dolzani and Daniela Platano and Eleonora Olivotto and Giuseppe Filardo and G Trisolino and Andrea Facchini and Rosa Maria Borz{\`i} and Riccardo Melic{\`o}ni},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND In osteoarthritis (OA), an inflammatory environment is responsible for the imbalance between the anabolic and catabolic activity of chondrocytes and, thus, for articular cartilage derangement. This study was aimed at providing further insight into the impairment of the anabolic cytokine IL-4 and its receptors in human OA cartilage, as well as the potential ability of IL-4 to antagonize the catabolic phenotype induced by IL-1β. METHODOLOGY/PRINCIPAL FINDINGS The in vivo expression… CONTINUE READING
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