Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance.

@article{Prasanth2004HumanOL,
  title={Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance.},
  author={Supriya Gangadharan Prasanth and Kannanganattu V Prasanth and Khalid J. Siddiqui and David L. Spector and Bruce W. Stillman},
  journal={The EMBO journal},
  year={2004},
  volume={23 13},
  pages={2651-63}
}
The initiation of DNA replication in S phase requires the prior assembly of an origin recognition complex (ORC)-dependent pre-replicative complex on chromatin during G1 phase of the cell division cycle. In human cells, the Orc2 subunit localized to the nucleus as expected, but it also localized to centrosomes throughout the entire cell cycle. Furthermore, Orc2 was tightly bound to heterochromatin and heterochromatin protein 1alpha (HP1alpha) and HP1beta in G1 and early S phase, but during late… CONTINUE READING
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