Human Oocyte-Derived Methylation Differences Persist in the Placenta Revealing Widespread Transient Imprinting

@inproceedings{SanchezDelgado2016HumanOM,
  title={Human Oocyte-Derived Methylation Differences Persist in the Placenta Revealing Widespread Transient Imprinting},
  author={Marta Sanchez-Delgado and Franck Court and Enrique Vidal and Jose Medrano and Ana Monteagudo-S{\'a}nchez and {\'A}lex Mart{\'i}n-Trujillo and Chiharu Tayama and Isabel Iglesias-Platas and Ivanela I. Kondova and Ronald Bontrop and Maria Eugenia Poo-Llanillo and Tom{\`a}s Marqu{\`e}s-Bonet and Kazuhiko Nakabayashi and Carlos Sim{\'o}n and David S. Monk},
  booktitle={PLoS genetics},
  year={2016}
}
Thousands of regions in gametes have opposing methylation profiles that are largely resolved during the post-fertilization epigenetic reprogramming. However some specific sequences associated with imprinted loci survive this demethylation process. Here we present the data describing the fate of germline-derived methylation in humans. With the exception of a few known paternally methylated germline differentially methylated regions (DMRs) associated with known imprinted domains, we demonstrate… CONTINUE READING
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