Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus-infected liver tissue.

@article{Piconese2014HumanOT,
  title={Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus-infected liver tissue.},
  author={Silvia Piconese and Eleonora Timperi and Ilenia Pacella and Valeria Schinzari and Claudio Tripodo and Massimo Rossi and Nicola Guglielmo and Gianluca Mennini and Gian Luca Grazi and Simona Di Filippo and Stefania Brozzetti and Katia Fazzi and Guido Antonelli and Maria Antonietta Lozzi and Massimo Sanchez and Vincenzo Barnaba},
  journal={Hepatology},
  year={2014},
  volume={60 5},
  pages={1494-507}
}
UNLABELLED Regulatory T cells (Tregs) can be considered as a mixed population of distinct subsets, endowed with a diverse extent and quality of adaptation to microenvironmental signals. Here, we uncovered an opposite distribution of Treg expansion, phenotype, and plasticity in different microenvironments in the same organ (liver) derived from patients with chronic hepatitis C: On the one side, cirrhotic and tumor fragments were moderately and highly infiltrated by Tregs, respectively… CONTINUE READING
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