Human Neutrophils Use Different Mechanisms To Kill Aspergillus fumigatus Conidia and Hyphae: Evidence from Phagocyte Defects.

@article{Gazendam2016HumanNU,
  title={Human Neutrophils Use Different Mechanisms To Kill Aspergillus fumigatus Conidia and Hyphae: Evidence from Phagocyte Defects.},
  author={Roel P. Gazendam and John L van Hamme and Anton T. J. Tool and Mark Hoogenboezem and J. Merlijn van den Berg and Jan C M Prins and Ljubomir Vitkov and Frank L van de Veerdonk and Timo K van den Berg and Dirk Roos and Taco Willem Kuijpers},
  journal={Journal of immunology},
  year={2016},
  volume={196 3},
  pages={1272-83}
}
Neutrophils are known to play a pivotal role in the host defense against Aspergillus infections. This is illustrated by the prevalence of Aspergillus infections in patients with neutropenia or phagocyte functional defects, such as chronic granulomatous disease. However, the mechanisms by which human neutrophils recognize and kill Aspergillus are poorly understood. In this work, we have studied in detail which neutrophil functions, including neutrophil extracellular trap (NET) formation, are… CONTINUE READING
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Protein kinase C isotype function in neutrophils

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