Human Neutrophil Elastase-Mediated Cleavage Sites of MMP-9 and TIMP-1: Implications to Cystic Fibrosis Proteolytic Dysfunction

@article{Jackson2010HumanNE,
  title={Human Neutrophil Elastase-Mediated Cleavage Sites of MMP-9 and TIMP-1: Implications to Cystic Fibrosis Proteolytic Dysfunction},
  author={Patricia L. Jackson and Xin Xu and Landon Wilson and Nathaniel M Weathington and John Paul Clancy and J Edwin Blalock and Amit Gaggar},
  journal={Molecular Medicine},
  year={2010},
  volume={16},
  pages={159-166}
}
Cystic fibrosis (CF) is a lethal genetic disorder characterized by airway remodeling and inflammation, leading to premature death. Recent evidence suggests the importance of protease activity in CF pathogenesis. One prominent protease, matrix metalloprotease (MMP)-9, demonstrates increased activity in CF individuals undergoing acute pulmonary exacerbation. This is thought to be mediated by both direct MMP-9 activation and the degradation of its natural inhibitor, tissue inhibitor of… CONTINUE READING
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