Human Neural Stem Cells Improve Cognition and Promote Synaptic Growth in Two Complementary Transgenic Models of Alzheimer’s Disease and Neuronal Loss

@inproceedings{Ager2015HumanNS,
  title={Human Neural Stem Cells Improve Cognition and Promote Synaptic Growth in Two Complementary Transgenic Models of Alzheimer’s Disease and Neuronal Loss},
  author={Rahasson R. Ager and Joy L. Davis and Andy Agazaryan and Francisca Benavente and Wayne W S Poon and Frank M Laferla and Mathew Blurton-Jones},
  booktitle={Hippocampus},
  year={2015}
}
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder, affecting over 35 million people worldwide. Pathologically, AD is characterized by the progressive accumulation of β-amyloid (Aβ) plaques and neurofibrillary tangles within the brain. Together, these pathologies lead to marked neuronal and synaptic loss and corresponding impairments in cognition. Current treatments, and recent clinical trials, have failed to modify the clinical course of AD; thus, the… CONTINUE READING
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