Human Natural Antibodies Cytotoxic to Pig Embryonic Brain Cells Recognize Novel Non-Galα1,3Gal-Based Xenoantigens

@article{Sumitran1999HumanNA,
  title={Human Natural Antibodies Cytotoxic to Pig Embryonic Brain Cells Recognize Novel Non-Galα1,3Gal-Based Xenoantigens},
  author={Suchitra Sumitran and Jihua Liu and Kimberly A. Czech and Birger Christensson and H{\aa}kan Widner and Jan Holgersson},
  journal={Experimental Neurology},
  year={1999},
  volume={159},
  pages={347-361}
}
Transplantation of porcine embryonic brain cells, including dopaminergic neurons, from ventral mesencephalon (VM) is considered a potential treatment for patients with Parkinson's disease. In the present study, we characterized the distribution among VM cells of the major porcine endothelial xenoantigen, the Galalpha1,3Gal epitope, and evaluated the cytotoxic effect of anti-Galalpha1,3Gal antibody-depleted and nondepleted human AB serum on VM cells. Overall levels of Galalpha1,3Gal-epitope… CONTINUE READING

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