Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility

  title={Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility},
  author={Dara M Strauss-Albee and Julia A. Fukuyama and Emily Liang and Yi Yao and Justin Ansel Jarrell and Alison L Drake and John Kinuthia and Ruth R. Montgomery and Grace John-Stewart and Susan P. Holmes and Catherine A. Blish},
  journal={Science Translational Medicine},
Innate natural killer (NK) cells are diverse at the single-cell level because of variegated expressions of activating and inhibitory receptors, yet the developmental roots and functional consequences of this diversity remain unknown. Because NK cells are critical for antiviral and antitumor responses, a better understanding of their diversity could lead to an improved ability to harness them therapeutically. We found that NK diversity is lower at birth than in adults. During an antiviral… CONTINUE READING
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