Human NF-κB repressing factor acts as a stress-regulated switch for ribosomal RNA processing and nucleolar homeostasis surveillance.

@article{Coccia2017HumanNR,
  title={Human NF-κB repressing factor acts as a stress-regulated switch for ribosomal RNA processing and nucleolar homeostasis surveillance.},
  author={Marta Coccia and Antonio Rossi and Anna Riccio and Edoardo Trotta and Maria Gabriella Santoro},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 5},
  pages={1045-1050}
}
The nucleolus, a dynamic nuclear compartment long regarded as the cell ribosome factory, is emerging as an important player in the regulation of cell survival and recovery from stress. In larger eukaryotes, the stress-induced transcriptional response is mediated by a family of heat-shock transcription factors. Among these, HSF1, considered the master regulator of stress-induced transcriptional responses, controls the expression of cytoprotective heat shock proteins (HSPs), molecular chaperones… CONTINUE READING