Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.

@article{Cornils2011HumanNK,
  title={Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.},
  author={Hauke Cornils and Reto S. Kohler and Alexander Hergovich and Brian A. Hemmings},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 7},
  pages={1382-95}
}
The G(1) phase of the cell cycle is an important integrator of internal and external cues, allowing a cell to decide whether to proliferate, differentiate, or die. Multiple protein kinases, among them the cyclin-dependent kinases (Cdks), control G(1)-phase progression and S-phase entry. With the regulation of apoptosis, centrosome duplication, and mitotic chromosome alignment downstream of the HIPPO pathway components MST1 and MST2, mammalian NDR kinases have been implicated to function in cell… CONTINUE READING