Human N-myc is closely related in organization and nucleotide sequence to c-myc

@article{Kohl1986HumanNI,
  title={Human N-myc is closely related in organization and nucleotide sequence to c-myc},
  author={N. Kohl and E. Legouy and R. DePinho and P. Nisen and Russell K. Smith and C. Gee and F. Alt},
  journal={Nature},
  year={1986},
  volume={319},
  pages={73-77}
}
N-myc, a cellular gene related to the c-myc proto-oncogene1–4, was originally identified on the basis of its very frequent amplification and overexpression in a restricted set of tumours, most notably human neuroblastomas1,2. That N-myc may have a causal role in the genesis of these tumours is suggested by the observation that in the rat embryo fibroblast co-transformation assay5,6 it has a transforming potential similar to that of c-myc7,8. The apparent structural and functional homology of N… Expand
Differential expression of myc family genes during murine development
TLDR
It is reported that high-level expression of N- and L-myc is very restricted with respect to tissue and stage in the developing mouse, while that of c- myc is more generalized, suggesting that differential myc gene expression has a role in mammalian development and that the normal expression patterns of these genes generally predict the types of tumours in which they are expressed or activated. Expand
Identification and characterization of the protein encoded by the human N-myc oncogene.
TLDR
The antisera to fragments of this protein were capable of histochemically identifying malignant cells in clinical specimens and appears to be part of the same proto-oncogene family as the c-myc protein. Expand
The myc family of nuclear proto-oncogenes.
  • W. Lee
  • Biology, Medicine
  • Cancer treatment and research
  • 1989
TLDR
The myc family of proto-oncogenes are united by a common gene structure and nucleotide homologies that were used to identify some of them initially, but differ markedly in their tissue specificity and developmental regulation of expression. Expand
The Structure and Function of the Normal c-myc Gene and Its Alteration in Malignant Cells
The c-myc gene, first discovered as the oncogene in an acute transforming avian retrovirus,(1) has subsequently been found to have important roles in the proliferation of both tumor and normal cells.Expand
Similarities and differences in the regulation of N-myc and c-myc genes in murine embryonal carcinoma cells.
TLDR
N-myc and c- myc expression was negatively regulated at a post-transcriptional level in F9 and PCC7 cells during differentiation to visceral endoderm and nerve-like tissue, respectively. Expand
Human proto-oncogene N-myc encodes nuclear proteins that bind DNA
N-myc is a gene whose amplification has been implicated in the genesis of several malignant human tumors. We have identified two proteins with molecular weights of 65,000 and 67,000 encoded by N-myc.Expand
Neoplastic transformation by the human gene N-myc.
TLDR
It is shown that N-myc can also act alone to elicit neoplastic growth of an established line of rat fibroblasts (Rat-1), lending further credibility to the role of N- myc in the genesis of human tumors, and establish a convenient assay that can be used to explore further the properties of both N- Myc. Expand
Neoplastic transformation by the human gene N-myc
Amplification and abundant expression of a gene known as N-myc are found frequently in advanced stages of human neuroblastoma and may play a role in the genesis of several malignant human tumors.Expand
Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.
  • B. C. Armstrong, G. Krystal
  • Biology, Medicine
  • Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
  • 1992
TLDR
N-myc and N-cym are unique in that they appear to be coregulated in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid, which suggests that their protein products may be functionally interrelated during normal development and oncogenesis. Expand
The human myc gene family: structure and activity of L-myc and an L-myc pseudogene.
TLDR
Comparison of the human and murine L-myc gene sequences indicate that the relatively large 5' and 3' untranslated regions are evolutionarily conserved, but that these sequences are totally divergent between the L-, c-, and N- myc genes. Expand
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References

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Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture
TLDR
It is shown that enhanced expression of N-myc subsequent to co-transfections of an N- myc expression vector and the mutant c-Ha-ras-1(EJ) (from the human bladder carcinoma cell line EJ) is a factor in tumorigenic conversion of secondary rat embryo cells. Expand
N-myc can cooperate with ras to transform normal cells in culture.
TLDR
It is demonstrated that a deregulated N-myc gene can cooperate with the activated Ha-ras oncogene to cause tumorigenic conversion of normal embryonic fibroblasts in a manner indistinguishable from the deregulated c- myc oncogen. Expand
Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29.
TLDR
The nucleotide sequence of v-myc is determined in the genome of the MC29 strain of myelocytomatosis virus, which encodes a hydrophilic polypeptide fused to a portion of the polyprotein encoded by the viral structural gene gag, and may account for the DNA-binding properties of the hybrid gag- myc-encoded protein. Expand
Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line
TLDR
It is demonstrated that sequences in normal human DNA homologous to the avian myc oncogene are present in multiple copies in the chromosomal DNA of the human leukaemia cell line HL-60, and this myc-related gene amplification is not present in other cultured human myeloid leukaems, including K-56214 and KG-115. Expand
Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29
TLDR
The nucleotide sequence of a genomic done prepared from a normal human library which contains all domains sharing homology with v-myc is isolated and determined to explore the relationship of the human cellular myc gene with the corresponding viral oncogene from MC29. Expand
Transposition and amplification of oncogene-related sequences in human neuroblastomas
TLDR
It is suggested that, in the eight lines which have amplified NB-19-21, the amplification units are overlapping, but not identical, and that transposition of the common sequences may occur prior to amplification. Expand
The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma
TLDR
The structure of the translocated gene and the nature of its linkage to the immunoglobulin locus and the presence of two c-myc promoters and consequently two long leader sequences raise novel possibilities for the activation of an oncogene. Expand
Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
TLDR
It is reported that in the case of RA-induced differentiation of neuroblastoma cell lines, a decreased level of expression is detected within 6 h of treatment and precedes both cell-cycle changes and morphological differentiation. Expand
Translocations among antibody genes in human cancer.
TLDR
A model for c- myc regulation is suggested that involves a trans-acting negative control element that might use as its target a highly conserved portion of the c-myc gene encoding two discrete transcriptional promoters. Expand
Amplification and expression of the c-myc oncogene in human lung cancer cell lines
Genetic changes involving the c-myc oncogene have been observed in human tumours. In particular, the c-myc gene is translocated in Burkitt's lymphoma1–3 and is amplified in the human promyelocyticExpand
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