Corpus ID: 310608

Human N-acetylation of benzidine: role of NAT1 and NAT2.

@article{Zenser1996HumanNO,
  title={Human N-acetylation of benzidine: role of NAT1 and NAT2.},
  author={T. Zenser and V. Lakshmi and T. Rustan and M. Doll and A. Deitz and B. Davis and D. Hein},
  journal={Cancer research},
  year={1996},
  volume={56 17},
  pages={
          3941-7
        }
}
These studies were designed to assess metabolism of benzidine and N-acetylbenzidine by N-acetyltransferase (NAT) NAT1 and NAT2. Metabolism was assessed using human recombinant NAT1 and NAT2 and human liver slices. For benzidine and N-acetylbenzidine, Km and Vmax values were higher for NAT1 than for NAT2. The clearance ratios (NAT1/NAT2) for benzidine and N-acetylbenzidine were 54 and 535, respectively, suggesting that N-acetylbenzidine is a preferred substrate for NAT1. The much higher NAT1 and… Expand
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