Human Myo19 Is a Novel Myosin that Associates with Mitochondria

@article{Quintero2009HumanMI,
  title={Human Myo19 Is a Novel Myosin that Associates with Mitochondria},
  author={Omar Alberto Chavarr{\'i}a Quintero and M. Divito and Rebecca C. Adikes and Melisa B. Kortan and Lindsay B Case and Audun J. Lier and Niki S. Panaretos and Stephanie Q. Slater and Michelle Rengarajan and M. Jos{\'e} Mur Feliu and Richard E. Cheney},
  journal={Current Biology},
  year={2009},
  volume={19},
  pages={2008-2013}
}
Mitochondria are pleomorphic organelles that have central roles in cell physiology. Defects in their localization and dynamics lead to human disease. Myosins are actin-based motors that power processes such as muscle contraction, cytokinesis, and organelle transport. Here we report the initial characterization of myosin-XIX (Myo19), the founding member of a novel class of myosin that associates with mitochondria. The 970 aa heavy chain consists of a motor domain, three IQ motifs, and a short… CONTINUE READING
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