Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.

@article{Haller2011HumanMP,
  title={Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.},
  author={Otto Haller and Georg Kochs},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2011},
  volume={31 1},
  pages={79-87}
}
The human myxovirus resistance protein 1 (MxA) is a key mediator of the interferon-induced antiviral response against a wide range of viruses. MxA expression is tightly regulated by type I and type III interferons, requires signal transducer and activator of transcription 1 signaling, and is not inducible directly by viruses or other stimuli. MxA shares many properties with the dynamin superfamily of large GTPases. It consists of 3 domains, namely, an N-terminal GTPase domain that binds and… CONTINUE READING
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