Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.

  title={Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.},
  author={Soo-Hyun Hahm and Ji Hyung Chung and L Satya Agustina and Se-Hee Han and In-Soo Yoon and Jong-Hwa Park and Lin-Woo Kang and Jin Woo Park and Jong Joo Na and Ye Sun Han},
  journal={Oncology letters},
  volume={4 6},
Etoposide (ETP) treatment of ataxia telangiectasia mutated (ATM) and Rad3-related protein (ATR)-, topoisomerase-binding protein-1 (TopBP1) and human MutY homolog (hMYH)-depleted cells results in a significant reduction in apoptotic signaling. The association between ATR or TopBP1 and hMYH increased following ETP treatment. In hMYH knockdown cells, the interaction between ATR and TopBP1 decreased following ETP treatment. We suggest that hMYH functions as a sensor of ETP-induced apoptosis. The… CONTINUE READING
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