Human MutY: gene structure, protein functions and interactions, and role in carcinogenesis

@article{Parker2003HumanMG,
  title={Human MutY: gene structure, protein functions and interactions, and role in carcinogenesis},
  author={Antony R. Parker and James R. Eshleman},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2003},
  volume={60},
  pages={2064-2083}
}
Faithful maintenance of the genome is crucial to the individual and the species. Oxidative DNA damage, such as 8-oxo-7,8-dihydroguanine (8-oxoG), poses a major threat to genomic integrity. 8-OxoG can mispair with 2′-deoxycytidine 5′-triphosphate or with 2′-deoxyadenosine triphosphate during DNA replication, forming C•8-oxoG and A•8-oxoG mispairs. Human MutY is responsible for recognition and removal of the inappropriately inserted adenine in an A•8-oxoG mispair. If unrepaired, the A•8-oxoG… CONTINUE READING