Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.

@article{Duckett1996HumanMR,
  title={Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.},
  author={Derek Duckett and James T Drummond and Alastair I. H. Murchie and Joyce T. Reardon and Aziz Sancar and David M. J. Lilley and Paul Modrich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 13},
  pages={6443-7}
}
Bacterial and mammalian mismatch repair systems have been implicated in the cellular response to certain types of DNA damage, and genetic defects in this pathway are known to confer resistance to the cytotoxic effects of DNA-methylating agents. Such observations suggest that in addition to their ability to recognize DNA base-pairing errors, members of the MutS family may also respond to genetic lesions produced by DNA damage. We show that the human mismatch recognition activity MutSalpha… CONTINUE READING

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AdenineNo subtypeCytosine
We show that the human mismatch recognition activity MutSalpha recognizes several types of DNA lesion including the 1,2-intrastrand d(GpG ) crosslink produced by cis - diamminedichloroplatinum(II ) , as well as base pairs between O6-methylguanine and thymine or cytosine , or between O4-methylthymine and adenine .
CytosineNo subtypeAdenine
We show that the human mismatch recognition activity MutSalpha recognizes several types of DNA lesion including the 1,2-intrastrand d(GpG ) crosslink produced by cis - diamminedichloroplatinum(II ) , as well as base pairs between O6-methylguanine and thymine or cytosine , or between O4-methylthymine and adenine .
AdenineNo subtypeThymine
We show that the human mismatch recognition activity MutSalpha recognizes several types of DNA lesion including the 1,2-intrastrand d(GpG ) crosslink produced by cis - diamminedichloroplatinum(II ) , as well as base pairs between O6-methylguanine and thymine or cytosine , or between O4-methylthymine and adenine .
ThymineNo subtypeAdenine
We show that the human mismatch recognition activity MutSalpha recognizes several types of DNA lesion including the 1,2-intrastrand d(GpG ) crosslink produced by cis - diamminedichloroplatinum(II ) , as well as base pairs between O6-methylguanine and thymine or cytosine , or between O4-methylthymine and adenine .
These observations imply direct involvement of the mismatch repair system in the cytotoxic effects of DNA - methylating agents and suggest that recognition of 1,2-intrastrand cis - diamminedichloroplatinum(II ) adducts by MutSalpha may be involved in the cytotoxic action of this chemotherapeutic agent .
These observations imply direct involvement of the mismatch repair system in the cytotoxic effects of DNA - methylating agents and suggest that recognition of 1,2-intrastrand cis - diamminedichloroplatinum(II ) adducts by MutSalpha may be involved in the cytotoxic action of this chemotherapeutic agent .
These observations imply direct involvement of the mismatch repair system in the cytotoxic effects of DNA - methylating agents and suggest that recognition of 1,2-intrastrand cis - diamminedichloroplatinum(II ) adducts by MutSalpha may be involved in the cytotoxic action of this chemotherapeutic agent .
These observations imply direct involvement of the mismatch repair system in the cytotoxic effects of DNA - methylating agents and suggest that recognition of 1,2-intrastrand cis - diamminedichloroplatinum(II ) adducts by MutSalpha may be involved in the cytotoxic action of this chemotherapeutic agent .
These observations imply direct involvement of the mismatch repair system in the cytotoxic effects of DNA - methylating agents and suggest that recognition of 1,2-intrastrand cis - diamminedichloroplatinum(II ) adducts by MutSalpha may be involved in the cytotoxic action of this chemotherapeutic agent .
These observations imply direct involvement of the mismatch repair system in the cytotoxic effects of DNA - methylating agents and suggest that recognition of 1,2-intrastrand cis - diamminedichloroplatinum(II ) adducts by MutSalpha may be involved in the cytotoxic action of this chemotherapeutic agent .
These observations imply direct involvement of the mismatch repair system in the cytotoxic effects of DNA - methylating agents and suggest that recognition of 1,2-intrastrand cis - diamminedichloroplatinum(II ) adducts by MutSalpha may be involved in the cytotoxic action of this chemotherapeutic agent .
These observations imply direct involvement of the mismatch repair system in the cytotoxic effects of DNA - methylating agents and suggest that recognition of 1,2-intrastrand cis - diamminedichloroplatinum(II ) adducts by MutSalpha may be involved in the cytotoxic action of this chemotherapeutic agent .
These observations imply direct involvement of the mismatch repair system in the cytotoxic effects of DNA - methylating agents and suggest that recognition of 1,2-intrastrand cis - diamminedichloroplatinum(II ) adducts by MutSalpha may be involved in the cytotoxic action of this chemotherapeutic agent .
CytosineNo subtypeThymine
We show that the human mismatch recognition activity MutSalpha recognizes several types of DNA lesion including the 1,2-intrastrand d(GpG ) crosslink produced by cis - diamminedichloroplatinum(II ) , as well as base pairs between O6-methylguanine and thymine or cytosine , or between O4-methylthymine and adenine .
ThymineNo subtypeCytosine
We show that the human mismatch recognition activity MutSalpha recognizes several types of DNA lesion including the 1,2-intrastrand d(GpG ) crosslink produced by cis - diamminedichloroplatinum(II ) , as well as base pairs between O6-methylguanine and thymine or cytosine , or between O4-methylthymine and adenine .
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