Human Multipotent Adult Progenitor Cells Are Nonimmunogenic and Exert Potent Immunomodulatory Effects on Alloreactive T-Cell Responses

@article{Jacobs2013HumanMA,
  title={Human Multipotent Adult Progenitor Cells Are Nonimmunogenic and Exert Potent Immunomodulatory Effects on Alloreactive T-Cell Responses},
  author={S. Jacobs and J. Pinxteren and V. Roobrouck and A. Luyckx and W. van't Hof and R. Deans and C. Verfaillie and M. Waer and A. Billiau and S. V. van Gool},
  journal={Cell Transplantation},
  year={2013},
  volume={22},
  pages={1915 - 1928}
}
Multipotent adult progenitor cells (MAPCs) are bone marrow-derived nonhematopoietic stem cells with a broad differentiation potential and extensive expansion capacity. A comparative study between human mesenchymal stem cells (hMSCs) and human MAPCs (hMAPCs) has shown that hMAPCs have clearly distinct phenotypical and functional characteristics from hMSCs. In particular, hMAPCs express lower levels of MHC class I than hMSCs and cannot only differentiate into typical mesenchymal cell types but… Expand
Clinical‐Grade Human Multipotent Adult Progenitor Cells Block CD8+ Cytotoxic T Lymphocytes
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