Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

@inproceedings{Gold2010HumanMA,
  title={Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells},
  author={Marielle C Gold and Stefania Cerri and Susan Smyk-Pearson and Meghan E. Cansler and Todd M. Vogt and Jacob Delepine and Ervina Winata and Gwendolyn M. Swarbrick and Wei-Jen Chua and Yik Yeung Lawrence Yu and Olivier Lantz and Matthew Simon Cook and Megan D. Null and David B. Jacoby and Melanie J Harriff and Deborah A. Lewinsohn and Thomas H{\o}st Hansen and David M. Lewinsohn},
  booktitle={PLoS biology},
  year={2010}
}
Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution analysis that nonclassically restricted CD8+ T cells are universally present, but predominate in Mtb-uninfected individuals. Interestingly, these Mtb-reactive cells expressed the Valpha7.2 T-cell receptor (TCR), were restricted by the… CONTINUE READING

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