Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers.

@article{Ray2011HumanMO,
  title={Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers.},
  author={Riju Ray and Kosha Ruparel and Andrew B Newberg and E. Paul Wileyto and James Loughead and Chaitanya R. Divgi and Julie A. Blendy and Jean Logan and Jon-Kar Zubieta and Caryn Lerman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 22},
  pages={9268-73}
}
Evidence points to the endogenous opioid system, and the mu-opioid receptor (MOR) in particular, in mediating the rewarding effects of drugs of abuse, including nicotine. A single nucleotide polymorphism (SNP) in the human MOR gene (OPRM1 A118G) has been shown to alter receptor protein level in preclinical models and smoking behavior in humans. To clarify the underlying mechanisms for these associations, we conducted an in vivo investigation of the effects of OPRM1 A118G genotype on MOR binding… CONTINUE READING
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