Human Mitochondrial Transcription Factor B2 Is Required for Promoter Melting during Initiation of Transcription.

Abstract

The mitochondrial transcription initiation machinery in humans consists of three proteins: the RNA polymerase (POLRMT) and two accessory factors, transcription factors A and B2 (TFAM and TFB2M, respectively). This machinery is required for the expression of mitochondrial DNA and the biogenesis of the oxidative phosphorylation system. Previous experiments… (More)
DOI: 10.1074/jbc.M116.751008

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