Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70

  title={Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70},
  author={Engin Baturcam and Natale Snape and T. H. Yeo and J. Schagen and E. Thomas and J. Logan and S. Galbraith and N. Collinson and S. Phipps and E. Fantino and P. Sly and K. Spann},
  journal={Journal of Innate Immunity},
  pages={52 - 64}
  • Engin Baturcam, Natale Snape, +9 authors K. Spann
  • Published 2016
  • Biology, Medicine
  • Journal of Innate Immunity
  • Asthmatics are highly susceptible to respiratory viral infections, possibly due to impaired innate immunity. However, the exact mechanisms of susceptibility are likely to differ amongst viruses. Therefore, we infected primary nasal epithelial cells (NECs) from adults with mild-to-moderate asthma, with respiratory syncytial virus (RSV) or human metapneumovirus (hMPV) in vitro and investigated the antiviral response. NECs from these asthmatics supported elevated hMPV but not RSV infection… CONTINUE READING
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