Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70

@article{Baturcam2016HumanMI,
  title={Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70},
  author={Engin Baturcam and Natale Snape and T. H. Yeo and J. Schagen and E. Thomas and J. Logan and S. Galbraith and N. Collinson and S. Phipps and E. Fantino and P. Sly and K. Spann},
  journal={Journal of Innate Immunity},
  year={2016},
  volume={9},
  pages={52 - 64}
}
  • Engin Baturcam, Natale Snape, +9 authors K. Spann
  • Published 2016
  • Biology, Medicine
  • Journal of Innate Immunity
  • Asthmatics are highly susceptible to respiratory viral infections, possibly due to impaired innate immunity. However, the exact mechanisms of susceptibility are likely to differ amongst viruses. Therefore, we infected primary nasal epithelial cells (NECs) from adults with mild-to-moderate asthma, with respiratory syncytial virus (RSV) or human metapneumovirus (hMPV) in vitro and investigated the antiviral response. NECs from these asthmatics supported elevated hMPV but not RSV infection… CONTINUE READING
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    References

    SHOWING 1-10 OF 42 REFERENCES
    Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma.
    • 50
    The plasmacytoid dendritic cell: at the cross-roads in asthma
    • 48
    • PDF
    Respiratory syncytial virus induces oxidative stress by modulating antioxidant enzymes.
    • 116
    Increased expression of heat shock protein 70 on airway cells in asthma and chronic bronchitis.
    • 71
    Impaired innate interferon induction in severe therapy resistant atopic asthmatic children
    • 142
    • PDF