Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70.

  title={Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70.},
  author={Engin Baturcam and Natale Snape and Tiong Han Yeo and Johanna Schagen and Emma Sophia Thomas and Jayden Logan and Sally Galbraith and Natasha M. Collinson and Simon Phipps and Emmanuelle Fantino and Peter D. Sly and Kirsten Spann},
  journal={Journal of innate immunity},
  volume={9 1},
Asthmatics are highly susceptible to respiratory viral infections, possibly due to impaired innate immunity. However, the exact mechanisms of susceptibility are likely to differ amongst viruses. Therefore, we infected primary nasal epithelial cells (NECs) from adults with mild-to-moderate asthma, with respiratory syncytial virus (RSV) or human metapneumovirus (hMPV) in vitro and investigated the antiviral response. NECs from these asthmatics supported elevated hMPV but not RSV infection… CONTINUE READING

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Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L - protein stability and RNA synthe

DC Munday, W Wu, +18 authors JA Hiscox
  • J Virol
  • 2015

Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations.

  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2014