Human Metabotropic Glutamate Receptor 1: mRNA Distribution, Chromosome Localization and Functional Expression of Two Splice Variants

@article{Stephan1996HumanMG,
  title={Human Metabotropic Glutamate Receptor 1: mRNA Distribution, Chromosome Localization and Functional Expression of Two Splice Variants},
  author={D. Stephan and C. Bon and J. Holzwarth and M. Galvan and R. Pruss},
  journal={Neuropharmacology},
  year={1996},
  volume={35},
  pages={1649-1660}
}
We have isolated clones from a human brain cDNA library coding for two splice variants of mGluR1. The combined sequences account for 6864 base pairs (bp) of the approximately 7 kilobase (kb) transcript seen on northern blots of human brain mRNA. The distribution of mGluR1 mRNA in human brain is similar to that found in rat brain and the gene for mGluR1 is localized on human chromosome 6. The mRNA for mGluR1 alpha contains an open reading frame that codes for a 1194 amino acid protein, which is… Expand
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