Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism

@inproceedings{Vasandan2016HumanMS,
  title={Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism},
  author={Anoop Babu Vasandan and Sowmya Jahnavi and Chandanala Shashank and Priya D. Prasad and Anujith Kumar and S. Jyothi Prasanna},
  booktitle={Scientific reports},
  year={2016}
}
Mesenchymal stem cells (MSCs) are speculated to act at macrophage-injury interfaces to mediate efficient repair. To explore this facet in-depth this study evaluates the influence of MSCs on human macrophages existing in distinct functional states. MSCs promoted macrophage differentiation, enhanced respiratory burst and potentiated microbicidal responses in naïve macrophages (Mφ). Functional attenuation of inflammatory M1 macrophages was associated with a concomitant shift towards alternatively… CONTINUE READING
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