Human Mesenchymal Stem Cells Inhibit Neutrophil Apoptosis: A Model for Neutrophil Preservation in the Bone Marrow Niche

@article{Raffaghello2008HumanMS,
  title={Human Mesenchymal Stem Cells Inhibit Neutrophil Apoptosis: A Model for Neutrophil Preservation in the Bone Marrow Niche},
  author={Lizzia Raffaghello and Giordano Bianchi and Maria Bianca Bertolotto and Fabrizio Montecucco and Alessandro Busca and Franco Dallegri and Luciano Ottonello and Vito Pistoia},
  journal={STEM CELLS},
  year={2008},
  volume={26}
}
Mesenchymal stem cells (MSC) establish close interactions with bone marrow sinusoids in a putative perivascular niche. These vessels contain a large storage pool of mature nonproliferating neutrophils. Here, we have investigated the effects of human bone marrow MSC on neutrophil survival and effector functions. MSC from healthy donors, at very low MSC:neutrophil ratios (up to 1:500), significantly inhibited apoptosis of resting and interleukin (IL)‐8‐activated neutrophils and dampened N‐formyl… Expand
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