Human Melatonin Production Decreases With Age

@article{Sack1986HumanMP,
  title={Human Melatonin Production Decreases With Age},
  author={R. Sack and A. Lewy and D. Erb and W. Vollmer and C. M. Singer},
  journal={Journal of Pineal Research},
  year={1986},
  volume={3}
}
The purpose of this study was to investigate the effects of time of year and demographic variables on the amplitude of melatonin production in normal human subjects. Melatonin production was estimated by measuring the overnight excretion of its major urinary metabolite, 6‐hydroxymelatonin. Urine was collected on three consecutive nights in the summer from a sample of 60 normal subjects balanced for sex and age. The collections were repeated in a subgroup during the winter. Melatonin production… Expand
A multinational study of the relationships between nighttime urinary melatonin production, age, gender, body size, and latitude
TLDR
Overnight urines were collected each month for 12–16 months from 321 normal subjects at 19 medical centers in 14 countries distributed on 5 continents at latitudes from 31 01 South to 77 00 North to negatively correlate with age, weight, and height. Expand
Individual Differences in the Amount and Timing of Salivary Melatonin Secretion
TLDR
Examining individual differences in a large sample of complete melatonin profiles not suppressed by light found an earlier occurrence of the onset of melatonin secretion was associated with an earlier wake time, more morningness and the absence of a bed partner. Expand
Human aging and melatonin. Clinical relevance
  • Y. Touitou
  • Medicine, Biology
  • Experimental Gerontology
  • 2001
Melatonin is a hormone produced mainly by the pineal gland and secreted primarily at night, when it reaches levels 10 times higher than those present in the daytime. The highest melatonin levels areExpand
Do plasma melatonin concentrations decline with age?
TLDR
The hypothesis that reduction of plasma melatonin concentration is a general characteristic of healthy aging is not supported and it is recommended that an assessment of endogenous melatonin be carried out before such treatment is used in older patients. Expand
Low and high melatonin excretors among healthy individuals
TLDR
The distinction between low and high nocturnal excretion and by inference secretion of melatonin most likely reflects genetically determined variable levels of the noradrenergic secretory drive and/or variable N‐acetyltransferase/hy‐droxyindole‐O‐methyltransferase enzymatic activity during the night. Expand
Physiological levels of melatonin contribute to the antioxidant capacity of human serum
TLDR
Results showed that both melatonin and TAS in human serum exhibited 24 hr variations with nocturnal peak values at 01:00 hr, and suggested that melatonin contributes to the total antioxidative capability of human serum. Expand
AGING AND THE CIRCADIAN RHYTHM OF MELATONIN: A CROSS-SECTIONAL STUDY OF CHINESE SUBJECTS 30–110 YR OF AGE
TLDR
A significant age-related decline in melatonin levels was found around the age of 60 and reached a very significantly lower level in subjects in their 70s and over 80 yr of age (P<0.01, when compared with age <60 yr). Expand
Clinical and Methodological Aspects of Melatonin Production in Affective Disorder.
TLDR
It appears from the present studies that melatonin production, at least in the rat, is not a good index of antidepressant-induced changes in β-adrenergic receptors, and Contrary to some popular theories of antidepressant drug action, these findings do not provide evidence for reduced noradrenaline neurotransmission during DMI therapy. Expand
Neuroendocrine rhythms and sleep in aging men.
TLDR
It is demonstrated that the normal process of aging involves alterations in the central mechanisms controlling the temporal organization of endocrine release in addition to a reduction of secretory outputs. Expand
Normative melatonin excretion: a multinational study
The present study on overnight urinary melatonin was conducted on the most geographically dispersed population to date, over a 1 year period, also covering a broad age range (18-62 years). An inverseExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 54 REFERENCES
Age-dependent reduction in serum melatonin concentrations in healthy human subjects.
TLDR
Serum melatonin concentrations were determined by RIA in 81 healthy humans, aged 1–92 yr and the results suggest that serum melatonin may be secreted under the agerelated neural control of pineal metabolism. Expand
The correlation between human plasma melatonin levels and urinary 6-hydroxymelatonin excretion.
TLDR
This study validates the comparison of plasma levels of the hormone or urinary levels of its metabolite to assess pineal gland production of melatonin in humans. Expand
Melatonin metabolite excretion during childhood and puberty.
TLDR
A significant increase in 6-hydroxymelatonin excretion was observed at the time of the onset of breast development (Tanner stage II) in girls and no similar difference was seen during puberty in males. Expand
Melatonin in humans.
  • M. Karásek, K. Winczyk
  • Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2006
TLDR
The basic data on melatonin significance in human physiology and in pathological processes as well as its possible therapeutic significance are reviewed and discussed. Expand
Measurement of urinary production rates of melatonin as an index of human pineal function.
TLDR
It is concluded that the use of deuterium-labelled melatonin coupled with quantitative gas chromatography-mass spectrometry offers a practical procedure for providing a clinically useful index of melatonin production in man. Expand
URINARY 6‐SULPHATOXY MELATONIN EXCRETION DURING THE HUMAN MENSTRUAL CYCLE
TLDR
Daily measurements made in two healthy ovulating women showed that both the total amount excreted/day and the proportion excreting during the sleep period remained relatively constant for each subject throughout the menstrual cycle, supporting the view that there are changes in melatonin production which correlate with cyclical reproductive endocrine function in the human. Expand
REDUCED NOCTURNAL MELATONIN SECRETION IN CHRONIC SCHIZOPHRENIA: RELATIONSHIP TO BODY WEIGHT
TLDR
The results suggest that the low levels of melatonin noted in studies on depressed patients may not be specific and that body weight must be controlled in subsequent studies ofmelatonin secretion in patients with psychiatric disease. Expand
Immunoassay of 6-hydroxymelatonin sulfate in human plasma and urine: abolition of the urinary 24-hour rhythm with atenolol.
TLDR
A simple and rapid RIA is described for 6-hydroxymelatonin sulfate in human plasma and urine that would allow noninvasive study of pineal function, applicable in particular to pediatric and long term circadian rhythm studies. Expand
Long-Term Studies on Immunoreactive Human Melatonin
TLDR
Intra-individual variations are seen at different times of the year at 2400 and 0800, with low values in spring and autumn and high values in summer and winter. Expand
Measurement of 6-hydroxymelatonin in human urine and its diurnal variations.
TLDR
A gas chromatographic-mass spectrometric assay has been developed and applied to the measurement of the major melatonin metabolite in human urine, and demonstrates a ten-fold diurnal variation. Expand
...
1
2
3
4
5
...