Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

@article{Takahashi2011HumanMS,
  title={Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors},
  author={Hidehisa Takahashi and Tari J. Parmely and Shigeo Sato and Chieri Tomomori-Sato and Charles A. S. Banks and Stephanie E. Kong and Henrietta Szutorisz and Selene K Swanson and Skylar A Martin-Brown and Michael P Washburn and Laurence Florens and Chris W. Seidel and Chengqi Lin and Edwin R Smith and Ali Shilatifard and Ronald C. Conaway and Joan W Conaway},
  journal={Cell},
  year={2011},
  volume={146},
  pages={92-104}
}
Promoter-proximal pausing by initiated RNA polymerase II (Pol II) and regulated release of paused polymerase into productive elongation has emerged as a major mechanism of transcription activation. Reactivation of paused Pol II correlates with recruitment of super-elongation complexes (SECs) containing ELL/EAF family members, P-TEFb, and other proteins, but the mechanism of their recruitment is an unanswered question. Here, we present evidence for a role of human Mediator subunit MED26 in this… CONTINUE READING
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