Human Maf 1 negatively regulates RNA Polymerase III transcription via the TFIIB family members Brf 1 and Brf 2

@inproceedings{Rollins2007HumanM1,
  title={Human Maf 1 negatively regulates RNA Polymerase III transcription via the TFIIB family members Brf 1 and Brf 2},
  author={Janet Rollins and Ingrid Veras and Stephanie Cabarcas and Ian M Willis and Laura Schramm},
  year={2007}
}
RNA polymerase III (RNA pol III) transcribes many of the small structural RNA molecules involved in processing and translation, thereby regulating the growth rate of a cell. Initiation of pol III transcription requires the evolutionarily conserved pol III initiation factor TFIIIB. TFIIIB is the molecular target of regulation by tumor suppressors, including p53, RB and the RB-related pocket proteins. However, our understanding of negative regulation of human TFIIIB-mediated transcription by… CONTINUE READING

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Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
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