Human MPS 1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores □ D

@inproceedings{Liu2003HumanM1,
  title={Human MPS 1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores □ D},
  author={Songtao Liu and Gordon K. T. Chan and James C. Hittle and Gregory H Fujii and Emma M. Lees and Tim J. Yen},
  year={2003}
}
We have determined that the previously identified dual-specificity protein kinase TTK is the human orthologue of the yeast MPS1 kinase. Yeast MPS1 (monopolar spindle) is required for spindle pole duplication and the spindle checkpoint. Consistent with the recently identified vertebrate MPS1 homologues, we found that hMPS1 is localized to centrosomes and kinetochores. In addition, hMPS1 is part of a growing list of kinetochore proteins that are localized to nuclear pores. hMPS1 is required by… CONTINUE READING

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