Human MMS21/NSE2 is a SUMO ligase required for DNA repair.

  title={Human MMS21/NSE2 is a SUMO ligase required for DNA repair.},
  author={Patrick Ryan Potts and Hongtao Yu},
  journal={Molecular and cellular biology},
  volume={25 16},
DNA repair is required for the genomic stability and well-being of an organism. In yeasts, a multisubunit complex consisting of SMC5, SMC6, MMS21/NSE2, and other non-SMC proteins is required for DNA repair through homologous recombination. The yeast MMS21 protein is a SUMO ligase. Here we show that the human homolog of MMS21 is also a SUMO ligase. hMMS21 stimulates sumoylation of hSMC6 and the DNA repair protein TRAX. Depletion of hMMS21 by RNA interference (RNAi) sensitizes HeLa cells toward… CONTINUE READING


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