Human METTL20 Is a Mitochondrial Lysine Methyltransferase That Targets the β Subunit of Electron Transfer Flavoprotein (ETFβ) and Modulates Its Activity*

@article{Maecki2014HumanMI,
  title={Human METTL20 Is a Mitochondrial Lysine Methyltransferase That Targets the $\beta$ Subunit of Electron Transfer Flavoprotein (ETF$\beta$) and Modulates Its Activity*},
  author={Jędrzej M. Małecki and Angela Yeuan Yen Ho and Anders Moen and Helge-Andr{\'e} Dahl and P{\aa}l {\O}. Falnes},
  journal={The Journal of Biological Chemistry},
  year={2014},
  volume={290},
  pages={423 - 434}
}
Background: Many proteins are modified by lysine methylation. Results: It is shown that the previously uncharacterized enzyme METTL20 methylates electron transfer flavoprotein β (ETFβ), thereby inhibiting its ability to mediate electron transfer from acyl-CoA dehydrogenases. Conclusion: METTL20-mediated methylation modulates the function of ETFβ. Significance: The first mitochondrial lysine-specific protein methyltransferase in animals is reported, and the resulting methylation is shown to have… 

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