Human MD-2 discrimination of meningococcal lipid A structures and activation of TLR4.

@article{Zimmer2007HumanMD,
  title={Human MD-2 discrimination of meningococcal lipid A structures and activation of TLR4.},
  author={Shanta M. Zimmer and Susu M Zughaier and Yih-ling Tzeng and David S. Stephens},
  journal={Glycobiology},
  year={2007},
  volume={17 8},
  pages={847-56}
}
MD-2, a eukaryotic accessory protein, is an essential component for the molecular pattern recognition of bacterial endotoxins. MD-2 interacts with lipid A of endotoxins [lipopolysaccharide (LPS) or lipooligosaccharide (LOS)] to activate human toll-like receptor (TLR) 4. The structure of lipid A influences the subsequent activation of human TLR4 and the immune response, but the basis for the discrimination of lipid A structures is unclear. A recombinant human MD-2 (rMD-2) protein was produced in… CONTINUE READING

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