Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.

@article{Dussaux2011HumanMC,
  title={Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.},
  author={Mathilde Duss{\'e}aux and Emmanuel Martin and Nacer Serriari and Isabelle P{\'e}guillet and Virginie Pr{\'e}mel and Delphine Louis and Maud Milder and Lionel le Bourhis and Claire Soudais and Emmanuel Treiner and Olivier Lantz},
  journal={Blood},
  year={2011},
  volume={117 4},
  pages={1250-9}
}
Mucosal-associated invariant T (MAIT) cells are very abundant in humans and have antimicrobial specificity, but their functions remain unclear. MAIT cells are CD161(hi)IL-18Rα(+) and either CD4(-)CD8(-) (DN) or CD8αβ(int) T cells. We now show that they display an effector-memory phenotype (CD45RA(-)CD45RO(+)CD95(hi)CD62L(lo)), and their chemokine receptor expression pattern (CCR9(int)CCR7(-)CCR5(hi)CXCR6(hi)CCR6(hi)) indicates preferential homing to tissues and particularly the intestine and… CONTINUE READING
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