Human Lymphocyte Apoptosis after Exposure to Influenza A Virus

@article{Nichols2001HumanLA,
  title={Human Lymphocyte Apoptosis after Exposure to Influenza A Virus},
  author={J. Nichols and Jean A Niles and N. Roberts},
  journal={Journal of Virology},
  year={2001},
  volume={75},
  pages={5921 - 5929}
}
ABSTRACT Infection of humans with influenza A virus (IAV) results in a severe transient leukopenia. The goal of these studies was to analyze possible mechanisms behind this IAV-induced leukopenia with emphasis on the potential induction of apoptosis of lymphocytes by the virus. Analysis of lymphocyte subpopulations after exposure to IAV showed that a portion of CD3+, CD4+, CD8+, and CD19+ lymphocytes became apoptotic (terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling… Expand
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