Human Luteinizing hormone-releasing hormone gene (LHRH) is located on short arm of chromosome 8 (region 8p11.2 → p21)

@article{YangFeng1986HumanLH,
  title={Human Luteinizing hormone-releasing hormone gene (LHRH) is located on short arm of chromosome 8 (region 8p11.2 → p21)},
  author={Teresa L. Yang-Feng and P. H. Seeburg and Uta Francke},
  journal={Somatic Cell and Molecular Genetics},
  year={1986},
  volume={12},
  pages={95-100}
}
Luteinizing hormone-releasing hormone (LHRH) is synthesized by hypothalamic neurons and affects the release of gonadotropic hormones from the anterior pituitary gland. A cDNA clone encoding the human LHRH precursor molecule was used to assign theLHRH gene to a human chromosome by in situ hybridization and Southern blot analysis. Metaphase spreads from two normal individuals were hybridized with3H -labeled LHRH-specific sequence. Of 120 cells analyzed, 33 had silver grains over the p11.2 → p21… 
The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8
TLDR
The localization of Gnrh, the murine homolog of luteinizing hormone-releasing hormone, to mouse chromosome 14 defines a hitherto unrecognized block of homology between man and mouse, and indicates that the region ofhomology between the human chromosome 8 short arm and mouse chromosome 8 is composed of two separate blocks.
Expression of mRNA for human type-I LHRH receptor transcript forms in human benign prostatic hyperplasia.
TLDR
The results suggest that L HRH-R-I gene may have more than two splice variants or uncharacterised transcript forms of LHRH- R-I, and support the merit of further investigation of the expression of this gene and its transcript forms in human BPH.
Subregional mapping of the human gonadotropin-releasing hormone receptor (GnRH-R) gene to 4q between the markers D4S392 and D4S409
TLDR
Nine yeast artificial chromosomes containing the gene that encodes the human gonadotropin-releasing hormone receptor (GnRH-R) gene are isolated by screening the YAC library of the Centre d'Etude du Polymorphisme Humain by the use of the polymerase chain reaction.
Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta.
TLDR
The GnRH gene has been cloned in several species, but the location of the promoter and the exact start of transcription have not previously been determined, and this characterization will allow hormonal regulatory studies to be performed using gene transfer techniques.
Second gene for gonadotropin-releasing hormone in humans.
TLDR
Molecular phylogenetic analysis shows that this second GnRH-II gene is likely the result of a duplication before the appearance of vertebrates, and predicts the existence of a third GnRH form in humans and other vertebrates.
Processing of the luteinizing hormone-releasing hormone precursor in the preoptic area and hypothalamus of the rat.
TLDR
It is demonstrated that multiple IR forms of the LHRH prohormone exist in the POH of the rat and that nerve terminals of theLHRH neurons contain L HRH, GAP1-56, and some lower mol wt GAP-like substances.
Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans.
TLDR
Functionally, there is growing evidence showing that both GnRH-I and Gn RH-II are potentially important autocrine and/or paracrine regulators in some extrapituitary compartments.
Normal structure of the gonadotropin-releasing hormone (GnRH) gene in patients with GnRH deficiency and idiopathic hypogonadotropic hypogonadism.
TLDR
It is concluded that a major rearrangement of the GnRH gene is not a common basis for IHH in humans, and polymorphisms or deletions or rearrangements involving more than 200 basepairs were excluded.
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TLDR
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