Human Lineage–Specific Amplification, Selection, and Neuronal Expression of DUF1220 Domains

@article{Popesco2006HumanLA,
  title={Human Lineage–Specific Amplification, Selection, and Neuronal Expression of DUF1220 Domains},
  author={M. Popesco and Erik J Maclaren and J. Hopkins and L. Dumas and M. Cox and L. Meltesen and L. McGavran and G. Wyckoff and J. Sikela},
  journal={Science},
  year={2006},
  volume={313},
  pages={1304 - 1307}
}
  • M. Popesco, Erik J Maclaren, +6 authors J. Sikela
  • Published 2006
  • Biology, Medicine
  • Science
  • Extreme gene duplication is a major source of evolutionary novelty. A genome-wide survey of gene copy number variation among human and great ape lineages revealed that the most striking human lineage–specific amplification was due to an unknown gene, MGC8902, which is predicted to encode multiple copies of a protein domain of unknown function (DUF1220). Sequences encoding these domains are virtually all primate-specific, show signs of positive selection, and are increasingly amplified generally… CONTINUE READING
    Gene copy number variation spanning 60 million years of human and primate evolution.
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