Human Leukocyte Antigen and Cytokine Receptor Gene Polymorphisms Associated With Heterogeneous Immune Responses to Mumps Viral Vaccine

@article{Ovsyannikova2008HumanLA,
  title={Human Leukocyte Antigen and Cytokine Receptor Gene Polymorphisms Associated With Heterogeneous Immune Responses to Mumps Viral Vaccine},
  author={I. Ovsyannikova and R. Jacobson and N. Dhiman and R. Vierkant and V. Pankratz and G. Poland},
  journal={Pediatrics},
  year={2008},
  volume={121},
  pages={e1091 - e1099}
}
OBJECTIVES. Mumps outbreaks continue to occur throughout the world, including in highly vaccinated populations. Vaccination against mumps has been successful; however, humoral and cellular immune responses to mumps vaccines vary significantly from person to person. We set out to assess whether HLA and cytokine gene polymorphisms are associated with variations in the immune response to mumps viral vaccine. METHODS. To identify genetic factors that might contribute to variations in mumps vaccine… Expand
Influence of cytokine gene variations on immunization to childhood vaccines.
TLDR
The data suggest that genetic variations in cytokine genes can influence vaccine-induced immune responses in infants, which in turn may influence vaccine efficacy. Expand
Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations.
TLDR
The results suggest that genetic variations within particular MHC genes can influence immune response to common childhood vaccinations, which in turn may influence vaccine efficacy. Expand
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines
TLDR
It is demonstrated that age, sex, and specific human genetic variants contribute to inter-individual variability in humoral immunity, and provides a basis to better understand disease pathogenesis. Expand
Replication of associations between cytokine and cytokine receptor single nucleotide polymorphisms and measles-specific adaptive immunophenotypic extremes.
TLDR
The findings demonstrate the importance of replicating genotypic-phenotypic associations, which can be achieved using immunophenotypic extremes and smaller sample sizes, and speculate that IL12RB1 polymorphisms may affect IL-12 and IL-23 binding and downstream effects, which are critical cytokine response to measles vaccine. Expand
Human leukocyte antigen genotypes in the genetic control of adaptive immune responses to smallpox vaccine.
TLDR
These data suggest that variations in antibody and cellular IFN-γ, IL-1β, TNF-α, and IL-6 immune responses after receipt of smallpox vaccine are genetically controlled by HLA genes or genes in close linkage disequilibrium to these alleles. Expand
SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine
TLDR
A genotyping study of Th1/Th2/inflammatory cytokines/cytokine receptors in healthy children to determine associations between individual single-nucleotide polymorphisms (SNPs)/haplotypes and immune outcomes after two doses of rubella vaccine identified individual SNPs/haplotype genes that appear to modulate immunity to rubella vaccination. Expand
Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination.
TLDR
The results validate previous findings and identify new plausible genetic determinants, including IL7R polymorphisms, regulating measles vaccine-induced immunity in a race-specific manner. Expand
Delayed adaptive immunity is related to higher MMR vaccine-induced antibody titers in children
TLDR
Investigation of whether early‐life environmental factors and adaptive immune maturation prior and close to measles–mumps–rubella (MMR) immunization relate to magnitudes of vaccine‐specific antibody titers indicate that delayed adaptiveimmune maturation before and in close proximity to immunization seems to be advantageous for the ability of children to respond with higher anti‐MMR antibody levels after vaccination. Expand
The role of HLA–DR–DQ haplotypes in variable antibody responses to Anthrax Vaccine Adsorbed
TLDR
Genetic associations between the immunoglobulin G antibody to protective antigen (AbPA) response to Anthrax Vaccine Adsorbed (AVA) in humans, and polymorphisms at HLA class I and class II loci are searched for. Expand
Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination.
TLDR
Specific polymorphisms in the vitamin A receptor, retinoic acid-inducible gene I, and tripartite motif 5 and 22 (TRIM5 and TRIM22) genes were significantly associated with rubella vaccine humoral immunity. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
Variation in vaccine response in normal populations.
TLDR
Data on the genetic determinants of immune responses to the measles vaccine support the importance of HLA genes in determining the variation in vaccine response, and may provide important insights for the design and development of new peptide-based vaccines against measles and other pathogens. Expand
HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: findings and implications for vaccine design.
TLDR
It is found that HLA supertypes, such as A3, B7, B44, B58, B62, and DR may play a role in modulating immune responses to the measles and mumps components of MMR vaccine. Expand
Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine.
TLDR
Better characterization of human leukocyte antigen (HLA) haplotypes could inform and improve the design of novel epitope-rich vaccines and help to predict protective immune responses at the individual and population level. Expand
HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination
TLDR
It is confirmed that HLA‐DRB1*07 (or a closely linked allele) and immunoregulatory cytokine gene polymorphisms correlate with variable immune response to recombinant HBV vaccines. Expand
Human leukocyte antigen polymorphisms: variable humoral immune responses to viral vaccines
TLDR
Recent research has demonstrated significant associations between vaccine response and human leukocyte antigen alleles, which explain why vaccine-induced humoral immune responses vary among individuals and between populations, and may also hold the key to the development of future generations of vaccines. Expand
Cellular immunity to mumps virus in young adults 21 years after measles-mumps-rubella vaccination.
TLDR
The results suggest a very long persistence of vaccine-induced anti-mumps virus cellular immunity. Expand
Extinction of the human leukocyte antigen homozygosity effect after two doses of the measles-mumps-rubella vaccine.
TLDR
Two doses of the MMR vaccine appear to induce sufficient antibody levels and lymphoproliferative responses against measles and rubella, regardless of HLA homozygosity status, however, children who are HLAhomozygous may be less protected against mumps compared with children who is heterozygous. Expand
Cell-mediated and humoral immunity to mumps virus antigen.
TLDR
Significant antibody responses, measured by enzyme-linked immunosorbent assay (ELISA), were observed after vaccination in all immunoglobulin classes, however, the elevation in antibody levels was usually transient in both seronegative and seropositive subjects. Expand
Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.
TLDR
Specific SNPs in the cytokine and cytokine receptor genes are significantly associated with variations in measures of the immune response to measles vaccination. Expand
Cytokine Polymorphisms Play a Role in Susceptibility to Ultraviolet B-Induced Modulation of Immune Responses after Hepatitis B Vaccination1
TLDR
Individual susceptibility to UVB radiation needs to be considered when studying the effects of UVB in humans, as exposure toUVB significantly suppressed Ab responses to hepatitis B in individuals with the minor variant for the IL-1β polymorphism. Expand
...
1
2
3
4
5
...