Human L1 Retrotransposition Is Associated with Genetic Instability In Vivo

@article{Symer2002HumanLR,
  title={Human L1 Retrotransposition Is Associated with Genetic Instability In Vivo},
  author={David E. Symer and Carla Connelly and Suzanne T. Szak and Emerita M. Caputo and Gregory J Cost and Giovanni Parmigiani and Jef D. Boeke},
  journal={Cell},
  year={2002},
  volume={110},
  pages={327-338}
}
Retrotransposons have shaped eukaryotic genomes for millions of years. To analyze the consequences of human L1 retrotransposition, we developed a genetic system to recover many new L1 insertions in somatic cells. Forty-two de novo integrants were recovered that faithfully mimic many aspects of L1s that accumulated since the primate radiation. Their structures experimentally demonstrate an association between L1 retrotransposition and various forms of genetic instability. Numerous L1 element… CONTINUE READING
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