Human Ku70/80 associates physically with telomerase through interaction with hTERT.

  title={Human Ku70/80 associates physically with telomerase through interaction with hTERT.},
  author={Weihang Chai and Lance P. Ford and Lisa Y. Lenertz and Woodring E Wright and Jerry W Shay},
  journal={The Journal of biological chemistry},
  volume={277 49},
Telomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. Here, we analyzed the physical association of Ku with human telomerase both in vivo and in vitro. Antibodies specific to human Ku proteins precipitated human telomerase in extracts from tumor… CONTINUE READING

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