Human Keratoconus Cell Contractility is Mediated by Transforming Growth Factor-Beta Isoforms

Abstract

Keratoconus (KC) is a progressive disease linked to defects in the structural components of the corneal stroma. The extracellular matrix (ECM) is secreted and assembled by corneal keratocytes and regulated by transforming growth factor-β (TGF-β). We have previously identified alterations in the TGF-β pathway in human keratoconus cells (HKCs) compared to… (More)
DOI: 10.3390/jfb6020422

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