Human KIT ligand promoter is positively regulated by HMGA1 in breast and ovarian cancer cells

@article{Treff2004HumanKL,
  title={Human KIT ligand promoter is positively regulated by HMGA1 in breast and ovarian cancer cells},
  author={Nathan R. Treff and Gregory A Dement and Jennifer E Adair and Rachel L Britt and Rong Nie and James E Shima and W. Edgar Taylor and Raymond Reeves},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={8557-8562}
}
KIT ligand (KL) and its receptor, c-kit, are coexpressed in many types of cancer cells and have been implicated in tumor growth and angiogenesis. While Sertoli cell-specific regulation of the KL promoter has been well characterized, regulation in cancer cells remains to be elucidated. We recently reported microarray results demonstrating that increased high-mobility group (HMG) A1a protein expression correlates with increased KL transcription in MCF-7 human breast cancer cells. Sequence… CONTINUE READING

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