Human JC virus nuclear factor 1 binding motifs and large tumor antigen region rquired for transactivation of late promoter.

@article{Kumar1996HumanJV,
  title={Human JC virus nuclear factor 1 binding motifs and large tumor antigen region rquired for transactivation of late promoter.},
  author={Karishma Kumar and Laxminarayana R. Devireddy and Seng Chuan Tang and Alan Pater and Mary M. Pater},
  journal={Journal of neurochemistry},
  year={1996},
  volume={67 2},
  pages={473-81}
}
The nuclear factor 1 (NF-1) motifs, NF-1 II/III, In the two 98-bp repeats of the transcription-regulatory region of JC virus (JCV), have a critical role in brain-specific transcription from the JCV early promoter-enhancer. In this study, the role of these motifs in transactivation of the JCV late promoter-enhancer (JCVL) was examined in differentiating glial P19 embryonal carcinoma cells. The expression of papovaviral large tumor antigen (T-Ag) in the glial cells was shown by double… CONTINUE READING

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