Human Intestinal Transporter Database: QSAR Modeling and Virtual Profiling of Drug Uptake, Efflux and Interactions

@article{Sedykh2012HumanIT,
  title={Human Intestinal Transporter Database: QSAR Modeling and Virtual Profiling of Drug Uptake, Efflux and Interactions},
  author={Alexander Sedykh and Denis Fourches and Jianmin Duan and Oliver Hucke and Michel Garneau and Hao Zhu and Pierre Bonneau and Alexander Tropsha},
  journal={Pharmaceutical Research},
  year={2012},
  volume={30},
  pages={996-1007}
}
Membrane transporters mediate many biological effects of chemicals and play a major role in pharmacokinetics and drug resistance. The selection of viable drug candidates among biologically active compounds requires the assessment of their transporter interaction profiles. Using public sources, we have assembled and curated the largest, to our knowledge, human intestinal transporter database (>5,000 interaction entries for >3,700 molecules). This data was used to develop thoroughly validated… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 44 references

Membrane transporters in drug development

Nature Reviews Drug Discovery • 2010
View 5 Excerpts
Highly Influenced

ABCmultidrug transporters: target for modulation of drug pharmacokinetics and drug-drug interactions

B Marquez, F. Van Bambeke
Curr Drug Targets • 2011
View 2 Excerpts

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