Human Immunodeficiency Virus Activates c‐Myc and Epstein‐Barr Virus in Human B Lymphocytes

@article{Astrin1992HumanIV,
  title={Human Immunodeficiency Virus Activates c‐Myc and Epstein‐Barr Virus in Human B Lymphocytes},
  author={S. Astrin and J. Laurence},
  journal={Annals of the New York Academy of Sciences},
  year={1992},
  volume={651}
}
We have established a line of malignantly transformed human B cells by infecting purified primary B lymphocytes with human immunodeficiency virus type 1 (HIV-1). This line, termed B-HIV1, may serve as a model system for a subset of AIDS-related B-cell lymphomas in which the transformed phenotype may be initiated and/or maintained through an HIV-1 gene product. The B-HIV1 line contains both Epstein-Barr virus (EBV) and HIV-1 genomes. In addition, the c-myc gene is expressed at levels 10 to 20… Expand
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