Human IgG production in vivo: determination of synthetic rate by nonradioactive tracer incorporation.

@article{Thornton1996HumanIP,
  title={Human IgG production in vivo: determination of synthetic rate by nonradioactive tracer incorporation.},
  author={Charles A. Thornton and Stephen Welle and Robert Griggs and George N. Abraham},
  journal={Journal of immunology},
  year={1996},
  volume={157 2},
  pages={950-5}
}
Exposure of Ab-secreting cells to selected hormones, cytokines, and drugs alters the rate of Ig production in vitro. Whether these effects are important clinically is unknown because there are no safe, reproducible, and appropriate techniques for measuring Ig synthesis in vivo. We developed a stable isotope tracer method to measure IgG secretion into plasma… CONTINUE READING